The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems.
نویسندگان
چکیده
منابع مشابه
The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems.
The process by which viruses destabilize endosomal membranes in an acidification-dependent manner has been mimicked with synthetic peptides that are able to disrupt liposomes, erythrocytes, or endosomes of cultured cells. Peptides containing the 20 amino-terminal amino acid sequence of influenza virus hemagglutinin as well as acidic derivatives showed erythrocyte lysis activity only when peptid...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1994
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)99963-1